<blockquote> <p>125</p> <p>&nbsp;</p> <p>Try this:</p> <ol> <li>Create the directory</li> </ol> <blockquote> <p>C:\Windows\SysWOW64\config\systemprofile\Desktop</p> </blockquote> <p>(for the 32-bit version of Excel/Office on a 64-bit Windows computer) or</p> <blockquote> <p>C:\Windows\System32\config\systemprofile\Desktop</p> </blockquote> <p>(for a 32-bit version of Office on a 32-bit Windows computer or a 64-bit version of Office on a 64-bit Windows computer).</p> <ol start="2"> <li>For the&nbsp;<em>Desktop</em>&nbsp;directory, add&nbsp;<em>Full control</em>&nbsp;permissions for the relevant user (for example in Win7 &amp; IIS 7 &amp; DefaultAppPool set permissions for user&nbsp;<em>IIS AppPool\DefaultAppPool</em>).</li> </ol> <p>Original post with answer:</p> <ul> <li><a href="https://social.msdn.microsoft.com/Forums/en-US/b81a3c4e-62db-488b-af06-44421818ef91/excel-2007-automation-on-top-of-a-windows-server-2008-x64?forum=innovateonoffice" rel="noreferrer">Excel 2007 automation on top of a Windows Server 2008 x64</a></li> </ul> </blockquote>